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Sciatica and Neuropathic Pain
- Sciatica causes radiating leg pain, burning, and electric shock sensations from the sciatic nerve
- Gabapentinoids and tricyclics are first-line but frequently provide inadequate relief
- Medical cannabis has its strongest evidence in neuropathic pain conditions
- Available via specialist prescription — many clinics offer telehealth for convenience
Sciatica with neuropathic features is among the most common pain conditions assessed at UK medical cannabis clinics.
The Evidence Base
- Multiple RCTs support cannabinoid use across neuropathic pain causes
- THC:CBD combination appears superior to THC alone in neuropathic pain studies
- Nabiximols (Sativex) is licensed in the UK for MS-related neuropathic pain — validating the mechanism
- Project Twenty21 UK data reports significant improvements in neuropathic pain patient scores
The neuropathic pain evidence base is the most robust across all chronic pain categories for medical cannabis use.
