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Menopause and the Endocannabinoid System
- Menopause affects all women, typically 45-55 years, with symptoms lasting up to a decade
- Common symptoms include hot flushes, sleep disturbance, mood changes, and joint pain
- The endocannabinoid system regulates temperature, mood, and pain — all relevant to menopause
- Medical cannabis is a complementary option alongside or instead of HRT for some women
Medical cannabis for menopause-related symptoms is an emerging clinical interest, particularly for women who cannot or prefer not to use HRT.
Symptoms That May Respond
- Sleep disturbance — often the most disabling menopausal symptom — may respond well to evening cannabis doses
- Joint and muscle pain in perimenopause is within the established cannabinoid evidence base
- Anxiety and mood changes may benefit from CBD-dominant formulations
- Evening dosing with oils is most appropriate for sleep and hot flush benefit
The combination of sleep improvement and pain reduction makes medical cannabis particularly interesting for menopausal women with musculoskeletal pain and insomnia.