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Week One: Starting Low
- Most prescriptions begin at a very low dose — often half or one-quarter of the target therapeutic dose
- Side effects are most likely to emerge in the first week: drowsiness, dry mouth, mild dizziness or light-headedness
- Do not drive, operate machinery or make significant decisions in the first week until you understand your individual response
- Keep a daily diary noting your dose, time, symptoms, side effects and sleep quality
Week one is about tolerability, not efficacy. The goal is not to feel a dramatic therapeutic effect — it is to establish that the product is tolerable and to give your body time to adapt to regular cannabinoid exposure.
Weeks Two to Three: Titrating Upward
- If week one was well-tolerated, your prescribing clinician will typically authorise a dose increase
- Increases are usually made every one to two weeks, moving incrementally towards the target dose
- Some patients feel meaningful benefit during titration; others do not notice significant effect until a stable dose is reached
- Carry on with the symptom diary — these notes are invaluable at your follow-up appointment
Patience during titration is essential. The instinct to increase the dose faster than instructed should be resisted. Rapid dose escalation is the most common cause of unnecessary side effects in new patients.
What Side Effects to Watch For
- Drowsiness that does not reduce after the first few days at a given dose — flag this to your clinician
- Increased anxiety or racing thoughts — more common with high-THC products, may resolve by switching to a more balanced formulation
- Heart palpitations, particularly in older patients — stop dosing and contact your clinician promptly
- Nausea — usually transient, often improved by taking the medication with food
None of these side effects mean you should stop treatment without speaking to your clinician first. Adjustments to dose, formulation or timing can resolve most issues without discontinuing what may ultimately be a very effective treatment.
One Month In: Your First Review
- Your first follow-up consultation typically occurs four to six weeks after starting treatment
- Bring your symptom diary, any questions and an honest assessment of what has and has not improved
- Discuss any side effects, changes in sleep, mood, pain levels and daily functioning
- The clinician may adjust your dose, switch products or recommend staying the course for another month
The first review sets the direction of your ongoing treatment. Patients who arrive prepared — with detailed notes and clear observations — get significantly more value from these appointments than those who attend without documentation.