What is Project Twenty21? UK Medical Cannabis Research

What is Project Twenty21?

• A UK-based patient registry and observational study run by Drug Science
• Launched in 2019 to generate real-world evidence on medical cannabis from UK patients
• Enrolled thousands of patients across multiple conditions and product types
• Represents one of the most comprehensive medical cannabis datasets in Europe

Project Twenty21 is building the UK-specific evidence base that will ultimately inform NHS commissioning, NICE guidelines, and prescribing frameworks.

Key Findings

• Statistically significant improvements in quality of life across the majority of enrolled patients
• Reductions in pain, anxiety, and sleep disturbance scores
• High proportions of patients reducing other medications including opioids and sleep aids
• Generally favourable safety profile — most adverse events mild and transient

The real-world evidence from Project Twenty21 directly supports the case for broader patient access to medical cannabis, including via the NHS.